Biophysics, v 54 N.1, p.4750, 2009 Nonlinear nature of the antiarrhythmic effects of the lidocaine

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Our results well agree with the results of theoretical investigation described in [5] as well as in [12].
Thus it must be concluded that little concentrations of the lidocaine raise the probability of polymorphic tachycardia while its greater concentrations suppress the excitability of heart tissue too much for the heart to can work efficiently. Probably the conclusion is correct and for the other blockaders of sodium channels.
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Fig.1. Effect of lidocaine on distribution of the experimental ventricular arrhythmias by the degree of polymorphism. Horizontal datum is the index V_{1i}, vertical  sample probability. In the upper right corner of every sample histogram, it is indicated an experiment phase and values of conditional probability of arrhythmias with V_{1i} lager than the value stated. 
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Fig.2. Distribution of the experimental ventricular arrhythmias by the degree of polymorphism in dependence of experiment duration. Notation is the same as in Fig. 1. 
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Fig.3. Conditional probability of arrhythmias with V_{1i} lager than the value stated (see the legend) in dependence on the lidocaine concentration in the physiological solution (generalization of Fig. 1). 